For more information on the possible side effects of methadone, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.
Take methadone hydrochloride tablets exactly as prescribed. Follow your doctor's directions exactly. Your doctor may change your dose based on your reactions to the medicine.
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result hinein toxic effects.
You may need to show airport staff the pharmacy Wortmarke for your medication. Always carry the original prescription-labeled container with you.
Patients should be apprised of the high risk of relapse to illicit drug use associated with discontinuation of methadone maintenance treatment.
Additional information on the potential risks of methadone may Beryllium derived from animal data. Methadone does not appear to Beryllium teratogenic hinein the rat or rabbit models. However, following large doses, methadone produced teratogenic effects hinein the guinea pig, hamster and mouse. One published study rein pregnant hamsters indicated that a single subcutaneous dose of methadone ranging from 31 to 185 mg/kg (the 31 mg/kg dose is approximately 2 times a human daily oral dose of 120 Magnesium/day on a mg/m2 Stützpunkt) on day 8 of gestation resulted hinein a decrease in the number of fetuses qua litter and an increase hinein the percentage of fetuses exhibiting congenital malformations described as exencephaly, cranioschisis, and “various other lesions”.
Hepatic Impairment – Methadone has not been extensively evaluated in patients with hepatic insufficiency. Methadone is metabolized by hepatic pathways, therefore patients with liver impairment may Beryllium at risk of accumulating methadone after multiple dosing.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not Beryllium used as a substitute for the knowledge and Gutachten of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication.
The severity of this syndrome will depend on the degree of physical dependence and the dose of the antagonist administered. If antagonists must Beryllium used to treat serious respiratory depression rein the physically dependent patient, the antagonist should be administered with extreme care and by titration with smaller than usual doses of the antagonist.
Hinein these patients, even usual therapeutic doses of methadone may decrease respiratory drive while simultaneously increasing airway resistance to the point of apnea. Alternative, non-opioid analgesics should Beryllium considered, and methadone should Beryllium used at the lowest effective dose and only under careful medical supervision.
For people with a head injury: This drug may cause increased pressure in your brain. This can raise your risk of complications or cause death.
Patients Methadontabletten 10 mg online seeking to discontinue methadone maintenance treatment of opioid dependence should Beryllium apprised of the high risk of relapse to illicit drug use associated with discontinuation of methadone maintenance treatment.
There is considerable variability in the appropriate Tarif of methadone taper in patients choosing medically supervised withdrawal from methadone treatment. It is generally suggested that dose reductions should Beryllium less than 10% of the established tolerance or maintenance dose, and that 10 to 14-day intervals should elapse between dose reductions.